FzM1.8, derives from FzM1, is an allosteric agonist of FZD4 with pEC50 of 6.4. FzM1.8 binds to FZD4 and activates the WNT/beta-catenin pathway, by promoting TCF/LEF transcriptional activity in the absence of any WNT ligand. FzM1.8 stabilizes FZD4 with an increased affinity for heterotrimeric G protein and stimulates the release of the Gbetagamma subunit that in turn activates PI3K[1].
Molekulargewicht:
322.31
Reinheit:
98.93
CAS Nummer:
[2204290-85-5]
Formel:
C18H14N2O4
Target-Kategorie:
Wnt,beta-catenin
Anwendungsbeschreibung:
MCE Product type: Reference compound
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