FzM1.8, derives from FzM1, is an allosteric agonist of FZD4 with pEC50 of 6.4. FzM1.8 binds to FZD4 and activates the WNT/beta-catenin pathway, by promoting TCF/LEF transcriptional activity in the absence of any WNT ligand. FzM1.8 stabilizes FZD4 with an increased affinity for heterotrimeric G protein and stimulates the release of the Gbetagamma subunit that in turn activates PI3K[1].
Molecular Weight:
322.31
Purity:
98.93
CAS Number:
[2204290-85-5]
Formula:
C18H14N2O4
Target:
Wnt,beta-catenin
Application Notes:
MCE Product type: Reference compound
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