ML345 is a potent and selective inhibitor of insulin-degrading enzyme (IDE) and NLRP3, with an IC50 of 188 nM against IDE. ML345 targets the Cys819 residue of IDE to inhibit IDE. ML345 selectively binds to NLRP3 in a non-covalent manner. ML345 inhibits inflammatory cytokines (IL-1beta, IL-6) and exhibits potent anti-inflammatory activity. ML345 exerts a protective effect against miscarriage[1][2].
Molekulargewicht:
479.54
Reinheit:
99.37
CAS Nummer:
[1632125-79-1]
Formel:
C21H22FN3O5S2
Target-Kategorie:
IDE,Interleukin Related,NOD-like Receptor (NLR)
Anwendungsbeschreibung:
MCE Product type: Reference compound
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