Danicopan (ACH-4471), a selective and orally active small-molecule factor D inhibitor, shows high binding affinity to human Factor D with Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits alternative pathway of complement (APC) activity, has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS)[1].
Molekulargewicht:
580.41
Reinheit:
99.91
CAS Nummer:
[1903768-17-1]
Formel:
C26H23BrFN7O3
Target-Kategorie:
Complement System
Anwendungsbeschreibung:
MCE Product type: Reference compound
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