Danicopan (ACH-4471), a selective and orally active small-molecule factor D inhibitor, shows high binding affinity to human Factor D with Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits alternative pathway of complement (APC) activity, has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS)[1].
Molecular Weight:
580.41
Purity:
99.91
CAS Number:
[1903768-17-1]
Formula:
C26H23BrFN7O3
Target:
Complement System
Application Notes:
MCE Product type: Reference compound
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