AKN-028 acetate, a novel tyrosine kinase (TK) inhibitor, is a potent, orally active FMS-like receptor tyrosine kinase 3 (FLT3) inhibitor with an IC50 value of 6 nM. AKN-028 acetate inhibits FLT3 autophosphorylation. AKN-028 acetate induces dose-dependent cytotoxic response (mean IC50=1 µM). AKN-028 acetate induces apoptosisby activation of caspase 3. AKN-028 acetate can be used in research of acute myeloid leukemia (AML).
Molekulargewicht:
362.39
Reinheit:
98.38
Formel:
C19H18N6O2
Target-Kategorie:
Apoptosis,Caspase,FLT3
Anwendungsbeschreibung:
MCE Product type: Reference compound
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