IW927 is a photochemically enhanced TNF-alpha-TNFR1 interaction inhibitor that blocks the binding of TNF-alpha to TNFRc1 with an IC50 value of 50 nM. IW927 binds reversibly to the TNFRc1 with weak affinity (Kd = 40-100 µM), covalently modifies the receptor via a photochemical reaction, and does not bind the related cytokine receptors TNFRc2 or CD40. IW927 disrupts TNFalpha-induced IkappaB phosphorylation with an IC50 value of 600 nM. IW927 can be used to develop light-independent inhibitors[1].
Molekulargewicht:
441.57
Reinheit:
99.23
CAS Nummer:
[389142-48-7]
Formel:
C22H23N3O3S2
Target-Kategorie:
TNF Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
