IW927 is a photochemically enhanced TNF-alpha-TNFR1 interaction inhibitor that blocks the binding of TNF-alpha to TNFRc1 with an IC50 value of 50 nM. IW927 binds reversibly to the TNFRc1 with weak affinity (Kd = 40-100 µM), covalently modifies the receptor via a photochemical reaction, and does not bind the related cytokine receptors TNFRc2 or CD40. IW927 disrupts TNFalpha-induced IkappaB phosphorylation with an IC50 value of 600 nM. IW927 can be used to develop light-independent inhibitors[1].
Molecular Weight:
441.57
Purity:
99.23
CAS Number:
[389142-48-7]
Formula:
C22H23N3O3S2
Target:
TNF Receptor
Application Notes:
MCE Product type: Reference compound
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