TM-233 is an inhibitor of the JAK/STAT and NF-kappaB signaling pathways, exhibiting significant antitumor activity. TM-233 reduces the expression of the anti-apoptotic protein Mcl-1 by inhibiting the phosphorylation of JAK2 and STAT3, and regulates its transcription by directly binding to the Mcl-1 gene promoter. Additionally, TM-233 prevents the translocation of NF-kappaB from the cytoplasm to the nucleus by inhibiting its DNA-binding activity, thereby reducing nuclear NF-kappaB expression. TM-233 shows potential in overcoming Bortezomib (HY-10227) resistance and can be applied in research related to multiple myeloma[1].
Molekulargewicht:
384.42
CAS Nummer:
[1103745-28-3]
Formel:
C25H20O4
Target-Kategorie:
Bcl-2 Family,JAK,NF-kappaB,STAT
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
