TM-233 is an inhibitor of the JAK/STAT and NF-kappaB signaling pathways, exhibiting significant antitumor activity. TM-233 reduces the expression of the anti-apoptotic protein Mcl-1 by inhibiting the phosphorylation of JAK2 and STAT3, and regulates its transcription by directly binding to the Mcl-1 gene promoter. Additionally, TM-233 prevents the translocation of NF-kappaB from the cytoplasm to the nucleus by inhibiting its DNA-binding activity, thereby reducing nuclear NF-kappaB expression. TM-233 shows potential in overcoming Bortezomib (HY-10227) resistance and can be applied in research related to multiple myeloma[1].
Molecular Weight:
384.42
CAS Number:
[1103745-28-3]
Formula:
C25H20O4
Target:
Bcl-2 Family,JAK,NF-kappaB,STAT
Application Notes:
MCE Product type: Reference compound
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