2-Methoxyestradiol-13C6 is the 13C-labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17beta-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa[1][2][3][4][5][6].
Molekulargewicht:
308.36
Formel:
C13 13C6H26O3
Target-Kategorie:
Apoptosis,Autophagy,Endogenous Metabolite,Isotope-Labeled Compounds,Microtubule/Tubulin,Reactive Oxygen Species (ROS)
Anwendungsbeschreibung:
MCE Product type: Isotope-Labeled Compounds
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