KBU2046 is an orally active transforming growth factor-beta (TGF-beta1) inhibitor. KBU2046 reduces integrin family protein expression, decreases Raf, RIPK1 and ERK phosphorylation to deactivate the ERK signaling pathway, and down-regulates genes linked to TGF-beta1 maturation. KBU2046 suppresses tumor cell motility, impedes cancer invasion and metastasis, and inhibits human ESCC growth and metastasis in a murine model. KBU2046 can be used for the researches of triple-negative breast cancer and esophageal squamous cell carcinoma[1][2].
Molekulargewicht:
242.25
Reinheit:
99.52
CAS Nummer:
[1143863-69-7]
Formel:
C15H11FO2
Target-Kategorie:
ERK,Integrin,Raf,RIP kinase,TGF-beta Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten