BMS-284640 is a synthetic sodium hydrogen exchange isomer-1 (NHE-1) inhibitor. BMS-284640 has a more than 380-fold higher NHE-1 inhibitory activity (IC50: 9 nM) compared to cariporide (HY-19693) and is more selective for NHE-1 over NHE-2 (IC50: 1.8 µM) and NHE-5 (IC50: 3.36 µM). BMS-284640 and its analogs also exhibit enhanced oral bioavailability and prolonged plasma half-life in rats.[1].
Molekulargewicht:
273.33
Reinheit:
99.75
CAS Nummer:
[230640-88-7]
Formel:
C15H19N3O2
Target-Kategorie:
Na+/H+ Exchanger (NHE)
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten