BMS-284640 is a synthetic sodium hydrogen exchange isomer-1 (NHE-1) inhibitor. BMS-284640 has a more than 380-fold higher NHE-1 inhibitory activity (IC50: 9 nM) compared to cariporide (HY-19693) and is more selective for NHE-1 over NHE-2 (IC50: 1.8 µM) and NHE-5 (IC50: 3.36 µM). BMS-284640 and its analogs also exhibit enhanced oral bioavailability and prolonged plasma half-life in rats.[1].
Molecular Weight:
273.33
Purity:
99.75
CAS Number:
[230640-88-7]
Formula:
C15H19N3O2
Target:
Na+/H+ Exchanger (NHE)
Application Notes:
MCE Product type: Reference compound
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