MRT199665, CAS [[1456858-57-3]]

Produktübersicht

• Artikelname: MRT199665, CAS [[1456858-57-3]]
• Artikelnummer: MCE-HY-120877
• Hersteller Artikelnummer: HY-120877
• Alternativnummer: MCE-HY-120877-50MG,MCE-HY-120877-5MG,MCE-HY-120877-10MG,MCE-HY-120877-25MG,MCE-HY-120877-10MMX1ML
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

MRT199665 is a potent and ATP-competitive, selective MARK/SIK/AMPK inhibitor with IC50s of 2/2/3/2 nM, 10/10 nM, and 110/12/43 nM for MARK1/MARK2/MARK3/MARK14, AMPKalpha1/AMPKalpha2, and SIK1/SIK2/SIK3, respectively[1]. MRT199665 causes apoptosis in MEF2C-activated human acute myeloid leukemias (AML) cells[2]. MRT199665 inhibits the phosphorylation of SIK substrate CRTC3 at S370[3].

Produkteigenschaften

• Molekulargewicht: 469.58
• Reinheit: 99.74
• CAS Nummer: [1456858-57-3]
• Formel: C28H31N5O2
• Target-Kategorie: AMPK,Apoptosis,MARK,Salt-inducible Kinase (SIK)

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound