MRT199665 is a potent and ATP-competitive, selective MARK/SIK/AMPK inhibitor with IC50s of 2/2/3/2 nM, 10/10 nM, and 110/12/43 nM for MARK1/MARK2/MARK3/MARK14, AMPKalpha1/AMPKalpha2, and SIK1/SIK2/SIK3, respectively[1]. MRT199665 causes apoptosis in MEF2C-activated human acute myeloid leukemias (AML) cells[2]. MRT199665 inhibits the phosphorylation of SIK substrate CRTC3 at S370[3].
Molecular Weight:
469.58
Purity:
99.74
CAS Number:
[1456858-57-3]
Formula:
C28H31N5O2
Target:
AMPK,Apoptosis,MARK,Salt-inducible Kinase (SIK)
Application Notes:
MCE Product type: Reference compound
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