CU-3 is the racemate of (5Z,2E)-CU-3. (5Z,2E)-CU-3 is a potent and selective inhibitor against the alpha-isozyme of DGK with an IC50 value of 0.6 µM, competitively inhibits the affinity of DGKalpha for ATP with a Km value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKalpha. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells[1].
Molekulargewicht:
392.47
CAS Nummer:
[2983265-35-4]
Formel:
C16H12N2O4S3
Target-Kategorie:
Apoptosis,DGK
Anwendungsbeschreibung:
MCE Product type: Reference compound
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