Pifithrin-alpha, p-Nitro, Cyclic (PFN-alpha) is cell-permeable and active-form p53 inhibitor. Pifithrin-alpha, p-Nitro, Cyclic is one order magnitude more active than Pifithrin-alpha in protecting cortical neurons exposed to Etoposide (ED50=30 nM). Pifithrin-alpha, p-Nitro, Cyclic behaves as a p53 posttranscriptional activity inhibitor. Pifithrin-alpha, p-Nitro, Cyclic do not prevent p53 phosphorylation on the S15 residue[1][2].
Molekulargewicht:
299.35
Reinheit:
99.37
CAS Nummer:
[60477-38-5]
Formel:
C15H13N3O2S
Target-Kategorie:
MDM-2/p53
Anwendungsbeschreibung:
Reference compound
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