20(S)-Hydroxycholesterol, CAS [[516-72-3]]

Produktübersicht

• Artikelname: 20(S)-Hydroxycholesterol, CAS [[516-72-3]]
• Artikelnummer: MCE-HY-12316
• Hersteller Artikelnummer: HY-12316
• Alternativnummer: MCE-HY-12316-5MG,MCE-HY-12316-50MG,MCE-HY-12316-25MG,MCE-HY-12316-100MG,MCE-HY-12316-10MG,MCE-HY-12316-10MMX1ML
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: 20alpha-Hydroxycholesterol

Produktbeschreibung

20(S)-Hydroxycholesterol (20alpha-Hydroxycholesterol) is an allosteric activator that selectively targets the Smoothened (Smo) of the Hedgehog pathway with an EC50 of ~30 µM (Hedgehog). 20(S)-Hydroxycholesterol binds to the extracellular cysteine-rich domain (CRD) of Smo in a stereoselective manner, activating downstream Gli transcription factors (without inducing transcription of receptor genes in the Wnt pathway). 20(S)-Hydroxycholesterol enhances osteogenic differentiation of bone marrow stromal cells and synergistically activates the Raf/MEK/ERK pathway with Simvastatin (HY-17502) to promote bone regeneration. 20(S)-Hydroxycholesterol can be used to study the mechanisms of developmental biology, oncology, bone, and angiogenesis[1][2][3].

Produkteigenschaften

• Molekulargewicht: 402.65
• Reinheit: 99.29
• CAS Nummer: [516-72-3]
• Formel: C27H46O2
• Target-Kategorie: Endogenous Metabolite,Smo

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Natural Products