20(S)-Hydroxycholesterol, CAS [[516-72-3]]

Product Overview

• Article Name: 20(S)-Hydroxycholesterol, CAS [[516-72-3]]
• Biozol Catalog Number: MCE-HY-12316
• Supplier Catalog Number: HY-12316
• Alternative Catalog Number: MCE-HY-12316-5MG,MCE-HY-12316-50MG,MCE-HY-12316-25MG,MCE-HY-12316-100MG,MCE-HY-12316-10MG,MCE-HY-12316-10MMX1ML
• Manufacturer: MedchemExpress
• Category: Biochemikalien
• Alternative Names: 20alpha-Hydroxycholesterol

Product Description

20(S)-Hydroxycholesterol (20alpha-Hydroxycholesterol) is an allosteric activator that selectively targets the Smoothened (Smo) of the Hedgehog pathway with an EC50 of ~30 µM (Hedgehog). 20(S)-Hydroxycholesterol binds to the extracellular cysteine-rich domain (CRD) of Smo in a stereoselective manner, activating downstream Gli transcription factors (without inducing transcription of receptor genes in the Wnt pathway). 20(S)-Hydroxycholesterol enhances osteogenic differentiation of bone marrow stromal cells and synergistically activates the Raf/MEK/ERK pathway with Simvastatin (HY-17502) to promote bone regeneration. 20(S)-Hydroxycholesterol can be used to study the mechanisms of developmental biology, oncology, bone, and angiogenesis[1][2][3].

Product Properties

• Molecular Weight: 402.65
• Purity: 99.29
• CAS Number: [516-72-3]
• Formula: C27H46O2
• Target: Endogenous Metabolite,Smo

Application Notes

• Application Notes: MCE Product type: Natural Products