ISX-9 (GMP), CAS [[832115-62-5]] Preis auf Anfrage

Produktübersicht

• Artikelname: ISX-9 (GMP), CAS [[832115-62-5]] Preis auf Anfrage
• Artikelnummer: MCE-HY-12323G
• Hersteller Artikelnummer: HY-12323G
• Alternativnummer: MCE-HY-12323G-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: Isoxazole 9 (GMP)

Produktbeschreibung

ISX-9 (Isoxazole 9) is a potent inducer of adult neural stem cell differentiation. ISX-9 activates Ca2+ influx through both voltage-gated Ca2+ channels and NMDA receptors and increases neuroD expression. ISX-9 also induces cardiomyogenic differentiation of Notch-activated epicardium-derived cells (NECs)[1][2][3]. In Vitro: ISX-9 promotes neurogenesis in vivo, enhancing the proliferation and differentiation of hippocampal subgranular zone (SGZ) neuroblasts, and the dendritic arborization of adult-generated dentate gyrus neurons. At 2.5-20 µM, ISX-9 has been shown to dose-dependently trigger neurogenesis and block gliogenesis in adult rat hippocampal stem cells through a calcium-activated signaling pathway dependent on myocyte-enhancer factor 2-dependent gene expression[1]. Molecular exploration of ISX-9-induced regulation of neurogenesis (via FACS and microarray of SGZ stem and progenitor cells) suggested the involvement of the myocyte-enhancer family of proteins (Mef2)[1]. In Vivo: ISX-9 (20 mg/kg, for 12 days, mice) treatment improves hippocampal function. ISX-9 enhances spatial memory ability in the Morris water maze test. ISX-9 enhances hippocampal neurogenesis and memory in vivo, and its effects are reliant on Mef2[1].

Produkteigenschaften

• Molekulargewicht: 234.27
• CAS Nummer: [832115-62-5]
• Formel: C11H10N2O2S
• Target-Kategorie: Calcium Channel

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: GMP Small Molecules