YC137 is a potent Bcl-2 antagonist with Kis of 1.3 µM and >100 µM for Bcl-2 and Bcl-xL when assayed in Bis-Tris buffer, respectively. YC137 inhibits the binding of the Bid BH3 peptide to Bcl-2, thus disrupting an interaction essential for the antiapoptotic activity of Bcl-2. YC137 selectively induces apoptosis of Bcl-2-dependent cells. YC137 has the potential for breast cancer research[1][2].
Molekulargewicht:
511.57
CAS Nummer:
[810659-53-1]
Formel:
C24H21N3O6S2
Target-Kategorie:
Apoptosis,Bcl-2 Family
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
