YC137 is a potent Bcl-2 antagonist with Kis of 1.3 µM and >100 µM for Bcl-2 and Bcl-xL when assayed in Bis-Tris buffer, respectively. YC137 inhibits the binding of the Bid BH3 peptide to Bcl-2, thus disrupting an interaction essential for the antiapoptotic activity of Bcl-2. YC137 selectively induces apoptosis of Bcl-2-dependent cells. YC137 has the potential for breast cancer research[1][2].
Molecular Weight:
511.57
CAS Number:
[810659-53-1]
Formula:
C24H21N3O6S2
Target:
Apoptosis,Bcl-2 Family
Application Notes:
MCE Product type: Reference compound
* VAT and and shipping costs not included. Errors and price changes excepted
