T-5342126 is a toll-like receptor 4 (TLR4) antagonist. It reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50=27.8 µM), as well as decreases LPS-induced IL-8, TNF-alpha, and IL-6 production in isolated human whole blood (IC50s=110.5, 315.6, and 318.4 µM, respectively). T-5342126 (82 mg/kg) reduces ethanol intake and the abundance of ionized calcium-binding adapter molecule 1 (Iba1), a marker of microglial activation, in the central nucleus of the amygdala in ethanol-dependent mice.
Molekulargewicht:
457.99
Reinheit:
98.1
CAS Nummer:
[956507-49-6]
Formel:
C25H32ClN3O3
Target-Kategorie:
Toll-like Receptor (TLR)
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
