T-5342126 is a toll-like receptor 4 (TLR4) antagonist. It reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50=27.8 µM), as well as decreases LPS-induced IL-8, TNF-alpha, and IL-6 production in isolated human whole blood (IC50s=110.5, 315.6, and 318.4 µM, respectively). T-5342126 (82 mg/kg) reduces ethanol intake and the abundance of ionized calcium-binding adapter molecule 1 (Iba1), a marker of microglial activation, in the central nucleus of the amygdala in ethanol-dependent mice.
Molecular Weight:
457.99
Purity:
98.1
CAS Number:
[956507-49-6]
Formula:
C25H32ClN3O3
Target:
Toll-like Receptor (TLR)
Application Notes:
MCE Product type: Reference compound
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