Lofepramine (Lopramine) is a modified tricyclic and orally active antidepressant. Lofepramine inhibits the uptake of Noradrenaline (NA) (HY-13715) and 5-hydroxytryptamine (5-HT) with IC50s of 2.7 µM and 11 µM, respectively. Lofepramine exerts its antidepressant activity by promoting noradrenergic neurotransmission. Lofepramine also enhances serotonergic neurotransmission by inhibiting neuronal uptake of 5-HT and tryptophan pyrrolase. Lofepramine exhibits significant anxiolytic properties. [1][2][3][4].
Molekulargewicht:
418.96
Reinheit:
99
CAS Nummer:
[23047-25-8]
Formel:
C26H27ClN2O
Target-Kategorie:
5-HT Receptor,Adrenergic Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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