PAWI-2, CAS [[1448427-02-8]]

Produktübersicht

• Artikelname: PAWI-2, CAS [[1448427-02-8]]
• Artikelnummer: MCE-HY-123929
• Hersteller Artikelnummer: HY-123929
• Alternativnummer: MCE-HY-123929-10MG,MCE-HY-123929-5MG,MCE-HY-123929-50MG,MCE-HY-123929-100MG,MCE-HY-123929-25MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

PAWI-2 is a p53-Activator and Wnt Inhibitor. PAWI-2 inhibits beta3-KRAS signaling independent of KRAS. PAWI-2 selectively inhibits phosphorylation of TBK1. PAWI-2 activates apoptosis (activation of caspase-3/7), and induces PARP cleavage. PAWI-2 promotes optineurin translocation into the nucleus and causes G2/M arrest. PAWI-2 reverses cancer stemness and overcomes drug resistance in an integrin beta3 KRAS-dependent human pancreatic cancer stem cells (hPCSCs). PAWI-2 inhibits growth of tumors from hPCSCs in orthopic xenograft mice model[1][2].

Produkteigenschaften

• Molekulargewicht: 371.45
• Reinheit: 99.29
• CAS Nummer: [1448427-02-8]
• Formel: C19H21N3O3S
• Target-Kategorie: Apoptosis,Caspase,IKK,MDM-2/p53,Wnt

Anwendungsbeschreibung

• Anwendungsbeschreibung: Reference compound