PAWI-2, CAS [[1448427-02-8]]

Product Overview

• Article Name: PAWI-2, CAS [[1448427-02-8]]
• Biozol Catalog Number: MCE-HY-123929
• Supplier Catalog Number: HY-123929
• Alternative Catalog Number: MCE-HY-123929-10MG,MCE-HY-123929-5MG,MCE-HY-123929-50MG,MCE-HY-123929-100MG,MCE-HY-123929-25MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

PAWI-2 is a p53-Activator and Wnt Inhibitor. PAWI-2 inhibits beta3-KRAS signaling independent of KRAS. PAWI-2 selectively inhibits phosphorylation of TBK1. PAWI-2 activates apoptosis (activation of caspase-3/7), and induces PARP cleavage. PAWI-2 promotes optineurin translocation into the nucleus and causes G2/M arrest. PAWI-2 reverses cancer stemness and overcomes drug resistance in an integrin beta3 KRAS-dependent human pancreatic cancer stem cells (hPCSCs). PAWI-2 inhibits growth of tumors from hPCSCs in orthopic xenograft mice model[1][2].

Product Properties

• Molecular Weight: 371.45
• Purity: 99.29
• CAS Number: [1448427-02-8]
• Formula: C19H21N3O3S
• Target: Apoptosis,Caspase,IKK,MDM-2/p53,Wnt

Application Notes

• Application Notes: Reference compound