ZLDI-8 is a Notch activating/cleaving enzyme ADAM-17 inhibitor and inhibits the cleavage of Notch protein. ZLDI-8 decreases the expression of pro-survival/anti-apoptosis and epithelial-mesenchymal transition (EMT) related proteins. ZLDI-8 is also a competitive and irreversible tyrosine phosphatase (Lyp) inhibitor with an IC50 of 31.6 µM and a Ki of 26.22 µM. ZLDI-8 inhibits the growth of MHCC97-H cells with an IC50 of 5.32 µM[1][2].
Molekulargewicht:
433.52
Reinheit:
98.47
CAS Nummer:
[667880-38-8]
Formel:
C24H23N3O3S
Target-Kategorie:
Apoptosis,Notch,Phosphatase
Anwendungsbeschreibung:
Reference compound
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