Raphin1 is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). Raphin1 binds strongly to the R15B-PP1c holophosphatase (Kd=33 nM), and shows ~30-fold selective in binding R15B-PP1c over R15A-PP1c. Raphin1 crosses the blood-brain barrier, and reduces organismal and molecular deficits in a mouse model of a protein misfolding disease[1].
Molekulargewicht:
231.08
Reinheit:
99.75
CAS Nummer:
[2022961-17-5]
Formel:
C8H8Cl2N4
Target-Kategorie:
Phosphatase
Anwendungsbeschreibung:
Reference compound
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