RNF5 inhibitor inh-02 is a potent inhibitor of E3 ubiquitin ligase RNF5/RMA1. RNF5 inhibitor inh-02 rescues F508del-CFTR function in F508del-CFTR-expressing immortalized cells (CFBE41o^, EC50 = 2.6 µM, FRT, EC 50 = 2.2 µM). RNF5 inhibitor inh-02 increases LC3IIB expression and autophagic vacuole number via reducing ATG4B ubiquitylation and promotes cell motility. RNF5 inhibitor inh-02 can be used for the study of cystic fibrosis[1].
Molekulargewicht:
384.50
Reinheit:
99.91
CAS Nummer:
[324579-65-9]
Formel:
C23H20N4S
Target-Kategorie:
Atg8/LC3,E1/E2/E3 Enzyme
Anwendungsbeschreibung:
Reference compound
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