RNF5 inhibitor inh-02 is a potent inhibitor of E3 ubiquitin ligase RNF5/RMA1. RNF5 inhibitor inh-02 rescues F508del-CFTR function in F508del-CFTR-expressing immortalized cells (CFBE41o^, EC50 = 2.6 µM, FRT, EC 50 = 2.2 µM). RNF5 inhibitor inh-02 increases LC3IIB expression and autophagic vacuole number via reducing ATG4B ubiquitylation and promotes cell motility. RNF5 inhibitor inh-02 can be used for the study of cystic fibrosis[1].
Molecular Weight:
384.50
Purity:
99.91
CAS Number:
[324579-65-9]
Formula:
C23H20N4S
Target:
Atg8/LC3,E1/E2/E3 Enzyme
Application Notes:
Reference compound
* VAT and and shipping costs not included. Errors and price changes excepted