ZT55 is an orally active and highly-selective JAK2 inhibitor with an IC50 value of 0.031 µM. ZT55 inhibits the proliferation of JAK2V617F-expressing HEL cell lines and induces apoptosis and cycle arrest. ZT-55 also effectively inhibits the growth of HEL xenograft tumours in a mice model. ZT-55 can be used in studies of myeloproliferative neoplasms, polycythemia vera and primary thrombocythemia[1].
Molekulargewicht:
296.32
Reinheit:
99.51
CAS Nummer:
[2138488-38-5]
Formel:
C17H16N2O3
Target-Kategorie:
Apoptosis,JAK
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
