ZT55 is an orally active and highly-selective JAK2 inhibitor with an IC50 value of 0.031 µM. ZT55 inhibits the proliferation of JAK2V617F-expressing HEL cell lines and induces apoptosis and cycle arrest. ZT-55 also effectively inhibits the growth of HEL xenograft tumours in a mice model. ZT-55 can be used in studies of myeloproliferative neoplasms, polycythemia vera and primary thrombocythemia[1].
Molecular Weight:
296.32
Purity:
99.51
CAS Number:
[2138488-38-5]
Formula:
C17H16N2O3
Target:
Apoptosis,JAK
Application Notes:
MCE Product type: Reference compound1
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