Poloppin, CAS [[683808-78-8]]

Produktübersicht

• Artikelname: Poloppin, CAS [[683808-78-8]]
• Artikelnummer: MCE-HY-124761
• Hersteller Artikelnummer: HY-124761
• Alternativnummer: MCE-HY-124761-10MG,MCE-HY-124761-25MG,MCE-HY-124761-1MG,MCE-HY-124761-5MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

Poloppin is a potent, cell penetrant inhibitor of the mitotic Polo-like kinase (PLK) (IC50=26.9 µM) and prevents the protein-protein interaction via the Polo-box domain (PBD) (Kd= 29.5 µM). Poloppin selectively kills cells expressing mutant KRAS, enhancing death in mitosis. Poloppin is used for the study of KRAS-mutant cancers as single agents, or in combination with c-MET inhibitors[1].

Produkteigenschaften

• Molekulargewicht: 438.24
• CAS Nummer: [683808-78-8]
• Formel: C20H15BrF3NO2
• Target-Kategorie: Autophagy,Mitosis,Polo-like Kinase (PLK)

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound