Poloppin is a potent, cell penetrant inhibitor of the mitotic Polo-like kinase (PLK) (IC50=26.9 µM) and prevents the protein-protein interaction via the Polo-box domain (PBD) (Kd= 29.5 µM). Poloppin selectively kills cells expressing mutant KRAS, enhancing death in mitosis. Poloppin is used for the study of KRAS-mutant cancers as single agents, or in combination with c-MET inhibitors[1].
Molecular Weight:
438.24
CAS Number:
[683808-78-8]
Formula:
C20H15BrF3NO2
Target:
Autophagy,Mitosis,Polo-like Kinase (PLK)
Application Notes:
MCE Product type: Reference compound
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