ITI-214 free base is a potent, CNS-active, orally bioavailable PDE1 inhibitor (Ki of 58 pM) with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters and ion channels. ITI-214 free base inhibits recombinant full-length human PDE1A, PDE1B and PDE1C with Kis of 33 pM, 380 pM and 35 pM, respectively. ITI-214 free base shows efficacy in various animal models of motor and cognitive functions[1][2].
Molekulargewicht:
507.56
Reinheit:
98
CAS Nummer:
[1160521-50-5]
Formel:
C29H26FN7O
Target-Kategorie:
Phosphodiesterase (PDE)
Anwendungsbeschreibung:
MCE Product type: Reference compound
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