AP22408 is a nonpeptide inhibitor against Src SH2 with an IC50 value of 0.3 µM. AP22408 inhibits rabbit osteoclast-mediated resorption of dentine, exhibits bone-targeting properties based on a hydroxyapatite adsorption assay and demonstrates in vivo antiresorptive activity in a parathyroid hormone-induced rat model. AP22408 is proming for rasearch of osteoporosis and other bone-related diseases such as Pagets disease, osteolytic bone metastasis and hypercalcemia associated with malignancy[1].
Molekulargewicht:
665.61
CAS Nummer:
[268741-43-1]
Formel:
C30H41N3O10P2
Target-Kategorie:
Src
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
