AP22408 is a nonpeptide inhibitor against Src SH2 with an IC50 value of 0.3 µM. AP22408 inhibits rabbit osteoclast-mediated resorption of dentine, exhibits bone-targeting properties based on a hydroxyapatite adsorption assay and demonstrates in vivo antiresorptive activity in a parathyroid hormone-induced rat model. AP22408 is proming for rasearch of osteoporosis and other bone-related diseases such as Pagets disease, osteolytic bone metastasis and hypercalcemia associated with malignancy[1].
Molecular Weight:
665.61
CAS Number:
[268741-43-1]
Formula:
C30H41N3O10P2
Target:
Src
Application Notes:
MCE Product type: Reference compound
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