AZ12253801 is an ATP-competitive IGF-1R tyrosine kinase inhibitor that shows ~10-fold selectivity over the insulin receptor. AZ12253801 inhibits IGF-1R-driven proliferation in 3T3 mouse fibroblasts (transfected with human IGF-1R) with an IC50 of 17 nmol/L. The IC50 for epidermal growth factor receptor (EGFR)-driven proliferation is 440 nmol/L. Anti-tumor activity.
Molekulargewicht:
402.45
CAS Nummer:
[851432-37-6]
Formel:
C21H22N8O
Target-Kategorie:
IGF-1R
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
