AZ12253801 is an ATP-competitive IGF-1R tyrosine kinase inhibitor that shows ~10-fold selectivity over the insulin receptor. AZ12253801 inhibits IGF-1R-driven proliferation in 3T3 mouse fibroblasts (transfected with human IGF-1R) with an IC50 of 17 nmol/L. The IC50 for epidermal growth factor receptor (EGFR)-driven proliferation is 440 nmol/L. Anti-tumor activity.
Molecular Weight:
402.45
CAS Number:
[851432-37-6]
Formula:
C21H22N8O
Target:
IGF-1R
Application Notes:
MCE Product type: Reference compound
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