TED-347 is a potent, irreversible, covalent and allosteric inhibitor at YAP-TEAD protein-protein interaction with an EC50 of 5.9 µM for TEAD4 Yap1 protein-protein interaction. TED-347 specifically and covalently bonds with Cys-367 within the central pocket of TEAD4 with a Ki of 10.3 µM. TED-347 blocks TEAD transcriptional activity and has antitumor activity[1].
Molekulargewicht:
313.70
Reinheit:
98.97
CAS Nummer:
[2378626-29-8]
Formel:
C15H11ClF3NO
Target-Kategorie:
YAP
Anwendungsbeschreibung:
MCE Product type: Reference compound
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