OSU-53 is an orally active AMPK activator (EC50: 0.3 µM) and a direct mTOR inhibitor. OSU-53 induces autophagy and increases conversion of LC3 I to LC3 II. OSU-53 also modulates energy homeostasis by suppressing fatty acid biosynthesis and shifting the metabolism to oxidation by up-regulating the expression of PGC1alpha and NRF-1. OSU-53 has antitumor activity in various tumor models, such as breast cancer and thyroid cancer[1][2].
Molekulargewicht:
583.60
CAS Nummer:
[1290069-19-0]
Formel:
C25H24F3N3O6S2
Target-Kategorie:
AMPK,Atg8/LC3,Autophagy,mTOR
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
