OSU-53 is an orally active AMPK activator (EC50: 0.3 µM) and a direct mTOR inhibitor. OSU-53 induces autophagy and increases conversion of LC3 I to LC3 II. OSU-53 also modulates energy homeostasis by suppressing fatty acid biosynthesis and shifting the metabolism to oxidation by up-regulating the expression of PGC1alpha and NRF-1. OSU-53 has antitumor activity in various tumor models, such as breast cancer and thyroid cancer[1][2].
Molecular Weight:
583.60
CAS Number:
[1290069-19-0]
Formula:
C25H24F3N3O6S2
Target:
AMPK,Atg8/LC3,Autophagy,mTOR
Application Notes:
MCE Product type: Reference compound
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