GMB-475, CAS [[2490599-18-1]]

Produktübersicht

• Artikelname: GMB-475, CAS [[2490599-18-1]]
• Artikelnummer: MCE-HY-125834
• Hersteller Artikelnummer: HY-125834
• Alternativnummer: MCE-HY-125834-50MG,MCE-HY-125834-5MG,MCE-HY-125834-25MG,MCE-HY-125834-10MMX1ML,MCE-HY-125834-10MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

GMB-475 is a potent BCR-ABL1 PROTAC based on Von Hippel-Lindau (VHL). GMB-475 targets the nutmeg pocket of ABL1 in an ectopic manner and degrades BCR-ABL1 protein through the ubiquitin proteasome pathway. GMB-475 inhibits the proliferation of human K562 cells and mouse Ba/F3 cells, and is used for the study of chronic myeloid leukemia. (Blue: VHL ligand (HY-125845), Black: Linker, Pink: BCR-ABL1 ligand (HY-11007))[1][2].

Produkteigenschaften

• Molekulargewicht: 861.93
• Reinheit: 98.69
• CAS Nummer: [2490599-18-1]
• Formel: C43H46F3N7O7S
• Target-Kategorie: Apoptosis,Bcr-Abl,JAK,PROTACs,STAT

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound