GMB-475 is a potent BCR-ABL1 PROTAC based on Von Hippel-Lindau (VHL). GMB-475 targets the nutmeg pocket of ABL1 in an ectopic manner and degrades BCR-ABL1 protein through the ubiquitin proteasome pathway. GMB-475 inhibits the proliferation of human K562 cells and mouse Ba/F3 cells, and is used for the study of chronic myeloid leukemia. (Blue: VHL ligand (HY-125845), Black: Linker, Pink: BCR-ABL1 ligand (HY-11007))[1][2].
Molecular Weight:
861.93
Purity:
98.69
CAS Number:
[2490599-18-1]
Formula:
C43H46F3N7O7S
Target:
Apoptosis,Bcr-Abl,JAK,PROTACs,STAT
Application Notes:
MCE Product type: Reference compound
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