Rhosin is a potent, specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction with a Kd of ~ 0.4 uM, and does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin induces cell apoptosis[1][2]. Rhosin promotes stress resiliency through enhancing D1-MSN plasticity and reducing hyperexcitability[3].
Molekulargewicht:
358.40
Reinheit:
98.74
CAS Nummer:
[1173671-63-0]
Formel:
C20H18N6O
Target-Kategorie:
Apoptosis,Ras
Anwendungsbeschreibung:
MCE Product type: Reference compound
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