Rhosin is a potent, specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction with a Kd of ~ 0.4 uM, and does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin induces cell apoptosis[1][2]. Rhosin promotes stress resiliency through enhancing D1-MSN plasticity and reducing hyperexcitability[3].
Molecular Weight:
358.40
Purity:
98.74
CAS Number:
[1173671-63-0]
Formula:
C20H18N6O
Target:
Apoptosis,Ras
Application Notes:
MCE Product type: Reference compound
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