NDI-091143 is a potent and high-affinity human ATP-citrate lyase (ACLY) inhibitor with an IC50 of 2.1 nM (ADP-Glo assay), a Ki of 7.0 nM and a Kd of 2.2 nM. NDI-091143 inhibits ACLY catalysis allosterically, by stabilizing large conformational changes in the citrate domain that indirectly block the binding and recognition of citrate[1].
Molekulargewicht:
453.84
Reinheit:
99.72
CAS Nummer:
[2375840-87-0]
Formel:
C20H14ClF2NO5S
Target-Kategorie:
ATP Citrate Lyase
Anwendungsbeschreibung:
MCE Product type: Reference compound
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