Platensimycin is an antibiotic produced by S. platensis that inhibits gram-positive bacteria by selectively inhibiting cellular lipid biosynthesis (IC50=0.1 µM). Platensimycin targets the beta-ketoacyl-acyl-carrier-protein synthase I/II, FabF/B, an enzyme that participates in the biosynthesis of fatty acids (IC50s=48 nM and 160 nM for S.aureus and E.coli enzymes, respectively). Platensimycin is a promising agent for overcoming antibiotic resistance.
Molekulargewicht:
441.47
Reinheit:
95.00
CAS Nummer:
[835876-32-9]
Formel:
C24H27NO7
Target-Kategorie:
Antibiotic,Bacterial
Anwendungsbeschreibung:
MCE Product type: Natural Products
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